منابع مشابه
Interleukin-11: review of molecular, cell biology, and clinical use.
F weights of recombinant human (rh) and murine IL-11 are 19,144 daltons and 19,154 daltons, respectively. Mature IRST ISOLATED IN 1990, interleukin-11 (IL-11) has proven to be a fascinating cytokine with pleiotropic effects on multiple tissues. Initially characterized as a hemahuman and primate IL-11 protein share 94% identity whereas human and murine proteins share 88% identity in the amino to...
متن کاملThe biology of interleukin-6.
B CELLS ARE the only eukaryotic cells that are able to produce antibody molecules. Their growth and differentiation into antibody producing cells require the presence of T cells and macrophages; the function of these cells was found to be replaced by soluble factors. 3 In the early i980s it was shown that at least two different kinds of factors were required in the regulation of B cell response...
متن کاملMediation of interleukin-11-dependent biological responses by a soluble form of the interleukin-11 receptor.
Interleukin-11 (IL-11) is a polyfunctional cytokine whose biological actions require a specific IL-11 receptor (IL-11R) and the transmembrane transducer gp130. Here we report the production of a soluble form of the murine IL-11R and demonstrate that it interacts with IL-11 ligand with high affinity. The affinity of IL-11 alone for gp130 is below the level of detection, but a complex of IL-11 an...
متن کاملBiology of interleukin 1.
Interleukin 1 (IL 1) is a polypeptide that is produced after infection, injury, or antigenic challenge. Although the macrophage is a primary source of IL 1, epidermal, epithelial, lymphoid, and vascular tissues synthesize IL 1. When IL 1 gains access to the circulation, it acts like a hormone and induces a broad spectrum of systemic changes in neurological, metabolic, hematologic, and endocrino...
متن کاملSignal transduction of interleukin-11 and interleukin-6 α-receptors
The cytokines Interleukin (IL)-11 and IL-6 are important mediators that regulate differentiation and proliferation of immune cells. Both cytokines bind to unique non-signaling α-receptors (IL-11R and IL-6R, respectively), and the resulting cytokine/cytokine receptor complexes recruit a homodimer of the signal-transducing β-receptor glycoprotein (gp)130. Gp130 is expressed ubiquitously, whereas ...
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ژورنال
عنوان ژورنال: STEM CELLS
سال: 1996
ISSN: 1066-5099,1549-4918
DOI: 10.1002/stem.5530110825